Jonathan Majors Nat Love Idris Elba Rufus Buck Regina King Trudy Smith Zazie Beetz Stagecoach Mary Delroy Lindo Bass Reeves Danielle Deadwyler Cuffee Lakeith Stanfield Cherokee Bill Edi Gathegi Bill Pickett RJ Cyler Jim Beckwourth Deon Cole Wiley Escoe Julio Cedillo Jesus Cortez Damon Wayans Jr. Monroe Grimes Woody McClain Clyde Grimes Jacobi Howard Angel Tait Fletcher Biggest Man on the Train Dylan Kenin General Abbott Andria B Langston Bank Teller Howard Ferguson Jr. Prison Lieutenant Mickey Dolan Jake Abbott Michael Beach Mr. Love DeWanda Wise Eleanor Love Chase W. Dillon Young Nat Sadiqua Bynum Eleanor Love Zacciah Hanson Prisoner Guard Stephanie Hill Train Passenger Vic Browder Prison Guard Steve Corona Maysville Bank Manager Peyton Jackson Woody J. Nathan Simmons Maysville Citizen Manny Rubio Father Esparza Aahkilah Cornelius Blue Lady Mark Rhino Smith Carson