Leonardo DiCaprio Ernest Burkhart Robert De Niro William King Hale Lily Gladstone Mollie Burkhart Jesse Plemons Tom White Tantoo Cardinal Lizzie Q Scott Shepherd Byron Burkhart Jason Isbell Bill Smith William Belleau Henry Roan Cara Jade Myers Anna John Lithgow Prosecutor Peter Leaward Brendan Fraser W.S. Hamilton JaNae Collins Reta Jillian Dion Minnie Louis Cancelmi Kelsie Morrison Tommy Schultz Blackie Thompson Tatanka Means John Wren Sturgill Simpson Henry Grammer Gary Basaraba Detective Burns Charlie Musselwhite Alvin Reynolds Pat Healy Agent John Burger Steve Witting Dr. James Shoun Steve Routman Dr. David Shoun Gene Jones Pitts Beatty Michael Abbott Jr. Agent Frank Smith J. C. MacKenzie Radio Announcer Jack White Radio Show Actor Larry Sellers Non-Hon-Zhin-Ga Barry Corbin Undertaker Turton Ben Hall Sara's Murderer Victor McCay Photos Hustler #2 Justin France Card Player Elden Henson Duke Burkhart Joey Oglesby Roy Bunch Kristin Keith Speakeasy Prostitute James Healy Jr. 2nd Insurance Man Mary Buss John Ramsey's Wife Steve Eastin Judge John C. Pollock Joe Chrest Lawyer Freeling Larry Fessenden Radio Voice (for Hale) Martin Scorsese Radio Show Producer