Shia LaBeouf Sam Witwicky Josh Duhamel Lennox John Turturro Simmons Tyrese Gibson Epps Rosie Huntington-Whiteley Carly Spencer Frances McDormand Mearing John Malkovich Bruce Brazos Patrick Dempsey Dylan Kevin Dunn Ron Witwicky Julie White Judy Witwicky Ken Jeong Jerry Wang Alan Tudyk Dutch Glenn Morshower General Morshower Lester Speight Eddie Buzz Aldrin Self Bill O'Reilly Self Ravil Isyanov Voshkod Markiss McFadden Lennox Team 'Baby Face' Scott C. Roe Lennox Team 'Nelson' James D. Weston II Lennox Team 'Tuens' Mikal Vega Epps Team 'Hooch' Kenny Sheard Epps Team 'Marc L' Josh Kelly Epps Team 'Stone' Keiko Agena Mearing's Aide LaMonica Garrett Morshower's Aide Yasen Peyankov Voshkod Associate Brett Stimely President Kennedy John H. Tobin President Nixon Drew Pillsbury Defense Secretary McNamara Tom Virtue Black Ops NASA Technician (1969) Kevin Sizemore Black Ops NASA Technician (1969) Don Jeanes Neil Armstrong (1969) Chris Sheffield Pimply Corporate Kid Mindy Sterling Female Insurance Agent Andrew Daly Mailroom Worker Maile Flanagan Accuretta Worker Luis Echagarruga SEAL Peter Cullen Optimus Prime (voice) Hugo Weaving Megatron (voice) James Remar Sideswipe (voice) Tom Kenny Wheelie (voice) Frank Welker Shockwave / Soundwave / Barricade (voice) John DiMaggio Leadfoot / Target (voice)