Ray Romano Manny (voice) John Leguizamo Sid (voice) Denis Leary Diego (voice) Queen Latifah Ellie (voice) Seann William Scott Crash (voice) Josh Peck Eddie (voice) Simon Pegg Buck (voice) Keke Palmer Peaches (voice) Jennifer Lopez Shira (voice) Neil deGrasse Tyson Neil deBuck Weasel (voice) Jesse Tyler Ferguson Shangri Llama (voice) Jessie J Brooke (voice) Adam DeVine Julian (voice) Wanda Sykes Granny (voice) Melissa Rauch Francine (voice) Michael Strahan Teddy (voice) Nick Offerman Gavin (voice) Max Greenfield Roger (voice) Lilly Singh Bubbles and Misty (voice) Chris Wedge Scrat (voice) Stephanie Beatriz Gertie (voice) Byron Thames Additional Voices (voice) Rif Hutton Additional Voices (voice) Holly Dorff Additional Voices (voice) Moosie Drier Additional Voices (voice) Carlos Ponce Mariachi Beaver (voice)